MACHINE LEARNING APPROACHES FOR PARSING COMORBIDITY/HETEROGENEITY IN ANTISOCIALITY AND SUBSTANCE USE DISORDERS: A PRIMER

Machine learning approaches for parsing comorbidity/heterogeneity in antisociality and substance use disorders: A primer

By some accounts, as many as 93% of individuals diagnosed with antisocial personality disorder (ASPD) or psychopathy also meet criteria for some form of substance use disorder (SUD).This high level of comorbidity, combined with an overlapping biopsychosocial profile, and potentially interacting features, has made it difficult to delineate the share

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ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases

Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation.The immune dysregulation can affect various organ systems: gut (e.g., inflammatory bowel disease), joints (e.g., rheumatoid arthritis)

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THE USE OF DENOSUMAB IN GIANT CELL TUMORS IN THE SACRUM

ABSTRACT Giant Cell Tumor (GCT), a benign tumor with local aggression, corresponds to 5% of primary tumors.Fifteen percent of these are located in the sacrum.En bloc resection is an effective treatment, but when it cannot be performed, Denosumab may be indicated as an alternative treatment.The objectives of this work are: to justify the indication;

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